Utilization of Nypa fruit in Alzheimer’s Disease: An in Silico Approach

MABBI – Research conducted by Ulfahri; Wardhani, R. Makatita, F.A. and Iskandar, I.W. from Hasanuddin University entitled Utilization of Nypa fruit in Alzheimer’s Disease: An in Silico Approach
This research aims to analyze the phytochemical potential of Nypa fruticans fruit for Alzheimer’s disease through molecular docking method. In 2007, it is estimated that 1 of 85 world population suffer from alzheimer and the number will be doubled in 20 years. The treatment of Alzheimer’s disease still relies on synthetic medicine. Indonesia as a mega-biodiversity country need to explore the natural resources for medicine, especially for Alzheimer’s disease treatment. Nypa fruticans fruit has several compounds like Kaempferol, Rutin, Quercetin, Chlorogenic Acid, Cinnamic Acid, Protocathecuic Acid, and Gallic Acid. These compounds could inhibit Acetylcholinesterase (AchE) enzyme activity. AchE is an enzyme that hydrolyzes acetylcholine to reduce the number of neurotransmitters. Biological activity of Nypa fruticans compound could be predicted with molecular docking and use score of binding affinity as a parameter for the ability on Acetylcholinesterase enzyme inhibition. The step consist of preparation of ligand and target protein, molecular docking, and drug-likeness test. The result shows that the compound of Nypa fruticans fruit potential for Alzheimer’s disease treatment, the compound who has the highest binding affinity is kaemferol of -9.6. (Tri/MABBI)

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