MABBI – Research conducted by Edward Kalkreuter, Satria A. Kautsar, Dong Yang, Christiana N. Teijaro, Chantal D. Bader, Lucas L. Fluegel, Christina M. Davis, Johnathon R. Simpson, Andrew D. Steele, Chun Gui, Song Meng, Gengnan Li, Konrad Viehrig, Fei Ye, Ping Su, Alexander F. Kiefer, Lukas Lauterbach, Angela Nichols, Alexis J. Cepeda, Wei Yan, Boyi Fan, Yanlong Jiang, Ajeeth Adhikari, Cheng-Jian Zheng, and Ben Shen from The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Lawrence Berkeley National Laboratory, Department of Discovery Chemistry Bristol, Skaggs Graduate School of Chemical and Biological Sciences, Prepaire Labs, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Centivax Inc. , University of Porto, Harvard University, China Academy of Chinese Medical Sciences, Nanjing Agricultural University, Nantong University, Rice University, Evercrisp Biosciences, and Naval Medical University entitled The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity
Actinobacteria, the bacterial phylum most renowned for natural product discovery, has been established as a valuable source for drug discovery and biotechnology but is underrepresented within accessible genome and strain collections. Herein, we introduce the Natural Products Discovery Center (NPDC), featuring 122,449 strains assembled over seven decades, the genomes of the first 8490 NPDC strains (7142 Actinobacteria), and the online NPDC Portal making both strains and genomes publicly available. A comparative survey of RefSeq and NPDC Actinobacteria highlights the taxonomic and biosynthetic diversity within the NPDC collection, including three new genera, hundreds of new species, and ∼7000 non-RefSeq gene cluster families. Selected examples demonstrate how the NPDC Portal’s strain metadata, genomes, and biosynthetic gene clusters can be leveraged using genome mining approaches. Our findings underscore the ongoing significance of Actinobacteria in natural product discovery, and the NPDC serves as an unparalleled resource for both Actinobacteria strains and genomes. (Tri/MABBI)
Read more:
https://www.biorxiv.org/content/10.1101/2023.12.14.571759v1.full.pdf+html
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